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MaxCell Microfiltration Cartridge CFP-6-D-65

Product No.：CFP-6-D-65
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MaxCell process-scale hollow fiber cartridges CFP-6-D-65

CROSS FLOW FILTRATION

General Information

MaxCell™ CFP-6-D-65 cartridges allow for cost-efficient, high-volume bioprocessing cross flow filtration operations (Fig 1). System sizing can be accurately scaled from laboratory- and pilot-scale cartridges, such as MidGee™ and Xampler™ cartridges.

The streamline design of the MaxCell CFP-6-D-65 cartridge enables effective utilization of space. In fact, MaxCell CFP-6-D-65 cartridges can be assembled with spacing as close as 18 cm (7 in) on center for incorporation into a compact membrane separations system. In addition, MaxCell cartridges can be used in place of competitive cartridges.
MaxCell Microfiltration Cartridge CFP-6-D-65 Product Data Sheet

Key benefits of MaxCell cartridges Fig 1. MaxCell cartridges can be built into custom systems to meet almost any process requirements and production capacities.

Cost-efficient cross flow filtration operations
Streamline design for efficient space utilization
Applicable in a wide variety of applications

The CFP-6-D-65 cartridges are provided with an integrally bonded threaded ring at each end. A 2 in sanitary adaptor and gasket are positioned at each end and sealed with a locking ring (Fig 2). The adapters are available in both straight and elbow design to accommodate a variety of high-capacity multicartridge manifold designs. The locking ring is easily tightened by hand or with a MaxCell wrench set. Permeate ports are of 1.5 in sanitary design.

MaxCell cartridges are available in three housing lengths that correspond to the lengths of laboratory- and pilot-scale cartridges. The full length housing size 85 with 0.5 mm inner diameter hollow fibers contains 13 m2 (140 ft2 ) of membrane area in a single, lightweight housing.

Incorporating Cytiva high pressure ultrafiltration membranes, MaxCell cartridges are capable of withstanding up to 3.4 barg (50 psig) transmembrane pressure. The combination of large surface area and high pressure capability provides extremely high productivity for a variety of large-scale bioprocessing applications.

Fig 2. MaxCell cartridges end-fitting design allows easy inspection and cleaning of the cartridge. Note that a choice of either a straight or elbow end adaptor kit is required for each new MaxCell cartridge application. Intended for large-volume bioprocessing applications, MaxCell cartridges are available in three different path lengths that correspond to smaller Cytiva laboratory- and pilot-scale cartridges to enable accurate and efficient, linear scale-up. Not only are MaxCell cartridges routinely used in a variety of conventional biopharmaceutical cross flow membrane applications, they are also used for high-capacity water purification and buffer depyrogenation. Cytiva offers membranes with a broad range of ultrafiltration nominal molecular weight cut-offs and microfiltration pore sizes. Most pore sizes are available in several membrane fiber inner diameters.

Applications

Typical applications for MaxCell hollow fiber cartridges are:

Concentration, purification, or diafiltration of monoclonal antibodies, proteins, vaccines, viruses, plasma, liposomes, or plasmids
Colloidal suspension concentration or diafiltration
Cell harvesting or clarification
Continuous buffer exchange
Removal of suspended solids, viruses, bacteria, or pyrogens
Harvesting or clarification of cell cultures
Lysate clarification
Continuous cell culture perfusion

Specifications

MaxCell cartridge specifications are listed in Table 1.

Table 1. Specifications for MaxCell cartridges

MaxCell cartridge physical dimensions

Housing size	Diameter		Length^†		End-fitting connections	Permeate connections
Housing size	cm	in	cm	in	End-fitting connections	Permeate connections
45	10.8	4.25	39.4	15.5	2 in sanitary	1.5 in sanitary
65	10.8	4.25	62.5	24.6	2 in sanitary	1.5 in sanitary
85	10.8	4.25	120.0	47.3	2 in sanitary	1.5 in sanitary

† Add 4.25 in (10.8 cm) for straight adaptors (2) at retentate ends.

MaxCell cartridge membrane area as a function of housing size and lumen diameter

Housing	Membrane Fiber Inner	Membrane Area size
Housing	mm	m²	ft²
45	0.5	3.5	37
	0.75	2.65	28.5
	1	2.3	25
65	0.5	6.1	66
65	1	4.4	47
85	0.5	13	140
85	1	9	95

MaxCell ultrafiltration cartridge transmembrane pressure as a function of operating temperature

1KMWC-30KMWC ultrafiltration membranes

Temperature	Maximum transmembrane pressure
°C	Barg	psig
< 10	3.7	60
10 to 25	3.4	50
25 to 50	3.1	45
50 to 80	2.3	35

100KMWC-750KMWC ultrafiltration membranes

Temperature	Maximum transmembrane pressure
°C	barg	psig
< 10	3.4	50
10 to 25	3.1	45
25 to 50	2.3	35
50 to 80	1.7	25

Ordering information

Housing size 45, microfiltration

Model number	Pore size μm	Membrane fiber inner diameter mm	Cartridge length†		Membrane area		Code number
			cm	in	m²	ft²
CFP-6-D-45	0.65	0.75	39.4	15.5	2.8	27	56-4109-17

Housing size 65, microfiltration

Model number	Pore size μm	Membrane fiber inner diameter mm	Cartridge length^†		Membrane area		Code number
			cm	in	m²	ft²
CFP-6-D-65	0.65	0.75	62.5	24.6	4.9	53	56-4108-12

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